Ndejje University earned a 1-0 win at SC Villa to earn the most shocking result of the first leg of the round of 32 at Bombo Barracks.
Brian Ssali scored the all-important winner to earn advantage over the Jogoos who will now need just a draw to eliminate the Jogoos.
At MTN Omondi stadium, Lugogo Police beat Fufa Big League side Calvary FC 5-0 with goals from Johnson Odong, Ben Ocen, Frank Tumwesigye Zaga, Muhamood Hassan and Brian Mayanja Muruli.
The Cops can now afford to lose 4-0 at the Green Light stadium in the return leg and still go through to the next round.
Bul also won 2-0 away to Black Powers while Onduparaka could only settle for a home draw with Luwero United.
Action continues on Tuesday with Mbarara City away to URA, MYDA visit Proline while record Cup winners Express take on Kyetume at Njeru.
Monday Results
SC Villa 0-1 Ndejje University
Water 1-2 Wakiso Giants
Terrazzo and Tiles 1-1 Maroons
Police 5-0 Calvary FC
Black Powers 0-2 BUL
Onduparaka 0-0 Luwero United
Tuesday April 6, 2021 Fixtures 4pm
Proline Vs MYDA – MTN stadium, Lugogo 3.30pm Live on TV
Gadaffi Vs Mbale Heroes – Kyabazinga stadium, Bugembe
Kitara Vs Kigezi Home Boyz – Kavumba
Kyetume Vs Express FC – Fufa Technical Centre, Njeru
Kataka Vs Tooro United – Mbale Municipal stadium
URA Vs Mbarara City – Arena of Visions, Ndejje