Ndejje University earned a 1-0 win at SC Villa to earn the most shocking result of the first leg of the round of 32 at Bombo Barracks.
Brian Ssali scored the all-important winner to earn advantage over the Jogoos who will now need just a draw to eliminate the Jogoos.
At MTN Omondi stadium, Lugogo Police beat Fufa Big League side Calvary FC 5-0 with goals from Johnson Odong, Ben Ocen, Frank Tumwesigye Zaga, Muhamood Hassan and Brian Mayanja Muruli.
The Cops can now afford to lose 4-0 at the Green Light stadium in the return leg and still go through to the next round.
Bul also won 2-0 away to Black Powers while Onduparaka could only settle for a home draw with Luwero United.
Action continues on Tuesday with Mbarara City away to URA, MYDA visit Proline while record Cup winners Express take on Kyetume at Njeru.
SC Villa 0-1 Ndejje University
Water 1-2 Wakiso Giants
Terrazzo and Tiles 1-1 Maroons
Police 5-0 Calvary FC
Black Powers 0-2 BUL
Onduparaka 0-0 Luwero United
Tuesday April 6, 2021 Fixtures 4pm
Proline Vs MYDA – MTN stadium, Lugogo 3.30pm Live on TV
Gadaffi Vs Mbale Heroes – Kyabazinga stadium, Bugembe
Kitara Vs Kigezi Home Boyz – Kavumba
Kyetume Vs Express FC – Fufa Technical Centre, Njeru
Kataka Vs Tooro United – Mbale Municipal stadium
URA Vs Mbarara City – Arena of Visions, Ndejje